Telomere Dysfunction drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome
In this paper, we provide genetic evidence that telomere dysfunction-induced DNA damage drives classical myelodysplastic syndrome phenotypes and alters common myeloid progenitor differentiation by repressing the expression of mRNA splicing/processing genes. This study established an intimate link across telomere biology, aberrant RNA splicing, and myeloid progenitor differentiation. Read the Abstract Download the PDF