Telomere Dysfunction promotes Non-reciprocal Translocations and Epithelial Cancers in Mice

This paper provides evidence that telomere attrition in aging telomerase-deficient p53 mutant mice promotes the development of epithelial cancers by a process of fusion-bridge breakage that leads to the formation of complex non-reciprocal translocations—a classical cytogenetic feature of human carcinomas.  Read the Abstract Download the PDF