Chromosomally Unstable Mouse Tumours have Genomic Alterations Similar to Diverse Human Cancers

In this study, we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. We determined that murine and human tumors have common biological processes driven by orthologous genetic events during their malignant evolution. These findings encourage …

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