Oncogenic Kras drives Invasion and maintains Metastases in Colorectal Cancer

To understand the role of oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Krasmut ) and conditional null alleles of Apc and Trp53 (iKAP). The iKAP model recapitulates human tumor progression from adenoma through metastases.
 
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