Telomere Dysfunction drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

In this paper, we provide genetic evidence that telomere dysfunction-induced DNA damage drives classical myelodysplastic syndrome phenotypes and alters common myeloid progenitor differentiation by repressing the expression of mRNA splicing/processing genes. This study established an intimate link across telomere biology, aberrant RNA splicing, and myeloid progenitor differentiation.

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