Epigenetic Activation of WNT5A drives Glioblastoma Stem Cell Differentiation and Invasive Growth

Here we developed a de novo glioblastoma multiforme model derived from immortalized human neural stem/progenitor cells (hNSCs) to enable precise system-level comparisons of pre-malignant and oncogene-induced malignant states of NSCs. This work identified the niche required for glioma stem cell growth in the brain.

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