Science

Epigenetic Activation of WNT5A drives Glioblastoma Stem Cell Differentiation and Invasive Growth

Here we developed a de novo glioblastoma multiforme model derived from immortalized human neural stem/progenitor cells (hNSCs) to enable precise system-level comparisons of pre-malignant and oncogene-induced malignant states of NSCs. This work identified the niche required for glioma stem cell growth in the brain.

Read the Abstract

Download the PDF

Get Insights From Ron

Sign up for the latest news and updates from Ron DePinho, MD