To understand the role of oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Krasmut ) and conditional null alleles of Apc and Trp53 (iKAP). The iKAP model recapitulates human tumor progression from adenoma through metastases.
Source: Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
