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Oncogenic Kras maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

We used an inducible KrasG12D-driven PDAC mouse model to establish that advanced PDAC remains strictly dependent on KrasG12D expression. This work provides in vivo mechanistic insights into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit.

Source: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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