p53 and Pten control Neural and Glioma Stem/Progenitor Cell Renewal and Differentiation

Here we showed that concomitant central nervous system (CNS)-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with notable clinical, pathological and molecular resemblance to primary glioblastoma multiforme in humans. 

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