Ron's Bio

p53 and Pten control Neural and Glioma Stem/Progenitor Cell Renewal and Differentiation

Here we showed that concomitant central nervous system (CNS)-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with notable clinical, pathological and molecular resemblance to primary glioblastoma multiforme in humans. 

Source: p53 and Pten control neural and glioma stemprogenitor cell renewal and differentiation

Get Insights From Ron

Sign up for the latest news and updates from Ron DePinho, MD