Synthetic Essentiality of Chromatin Remodelling Factor CHD1 in PTEN-deficient Cancer

Established the principle of “synthetic essentiality” and identified CHD1 as a synthetic-essential gene in PTEN-deficient cancers. This study identified a novel PTEN pathway in cancer and provided a framework for the discovery of ‘trackable’ targets in cancers that harbor specific tumor-suppressor deficiencies.

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