This study demonstrated that telomere dysfunction activates p53, which in turn binds and represses PGC-1α and PGC-1β promoters, thereby establishing a direct link between telomere and mitochondrial biology. Read the Abstract Download the PDF
Telomere Dysfunction induces Metabolic and Mitochondrial Compromise Read More »
This model-informed progression analysis, together with genetic, functional and translational studies, established SMAD4 as a key regulator of PCA progression in mice and humans. This work led to the development of a clinical test enabling stratification of men with prostate cancer into benign and aggressive groups. Read the Abstract Download the PDF
SMAD4-Dependent Barrier Constrains Prostate Cancer Growth and Metastatic Progression Read More »
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