The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify […]
Telomeres: History, Health, and Hallmarks of Aging Read More »
Just in – our paper was selected as the COVER for Cancer Discovery. Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSC). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM, prompting us to conduct a gain-of-function screen
A study has revealed the protein responsible for causing pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer. The researchers, from the University of Texas MD Anderson Cancer Center, US, validated ubiquitin-specific protease 21 (UPS21) as a frequently amplified gene and a potential druggable target. “The USP family is the largest group of
New Target for Pancreatic Cancer Read More »
As candidate early detection tests for PDAC come online, one of the key challenges is figuring out who to screen, i.e., at greatest risk. For those with new-onset diabetes which modestly increases overall risk relative to the general population, this model could enrich for those new-onset diabetics harboring an occult PDAC, i.e., optimal candidates for
Model to Determine Risk of Pancreatic Cancer Read More »
The current paradigm has proven failed. We need to bring great science, drug development and clinical experts together in a coordinated fashion to help best prosecute opportunities.
How to Accelerate Our Access To Tomorrow’s Medicine Today Read More »
Two new biotech companies are in development to treat diseases and help patients in a profoundly impactful way.
New Companies I’m Excited About Read More »
Most women with early-stage breast cancer may be able to avoid chemotherapy, a new study finds. Researchers determined that patients with smaller-sized tumors that had not spread to the lymph nodes did just as well without chemo as those who got the treatment, according to the study presented Sunday at the American Society of Clinical
Many women with early breast cancer may not need chemo, study finds Read More »
During her years of struggle with lung cancer, Deanna Brinkman has avidly researched her specific type of disease. So when an immunotherapy drug failed to stop it in late 2016 she understood the implications all too well. “I called my oncologist,” she recalls. “We have a superb relationship. He knew that I knew what I
A Failed Drug is Showing Unprecedented Success Against a Previously Impervious Mutation Read More »
Earlier this month, I had the privilege of giving two scientific talks: one at a Grand Rounds lecture hosted by NCI’s Center for Cancer Research, and a second held at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University. Both talks focused on my research and observations on the dynamic interplay between cancer and
The Challenging Landscape of Cancer and Aging: Charting a Way Forward Read More »
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