JoeDPnew

Protect Your Science and Its Impact

Be strategic in securing intellectual property rights for the benefit of your patients As scientists, we are hardwired to communicate our breakthrough discoveries openly and rapidly in order to advance knowledge for the benefit of humanity. While admirable, scientific publications alone do not cure patients. Alleviation of pain and suffering occurs only when such knowledge …

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Cancer Research and Investment Opportunities

Cancer exacts a steep social and economic toll, especially as an aging world population creates increased cancer rates. The investment community plays a critical role in supporting the conversion of entrepreneurial innovation into products and platforms that reduce the burden of cancer throughout the world. A viable investment strategy rests on an understanding of the …

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Telomere Dysfunction Instigates Inflammation in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, in murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) results in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which …

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Genetic and Biological Hallmarks of Colorectal Cancer

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape …

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Watch On-Demand Sessions: 2021 Fifth International Vatican Council

You can now view all of the speaker sessions from the May 6-8 Fifth International Vatican Conference on the conference website. The 3-day virtual event, offered by the Vatican’s Pontifical Council for Culture and Cura Foundation, featured over 100 global leaders in science, faith, medicine and technology, all exploring and fostering new conversations about how innovation and novel …

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Leadership Series 5: Leading in a Turbulent Time

Leaders have an obligation to continually fine-tune their leadership approach in disruptive times to maximize the success and resilience of their teams. In my last leadership article, I noted that the increasing pace of change in healthcare has increased the need to build more interdependent, highly-adaptive, and high-performing teams. The pandemic has accelerated change and …

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Cancer Moonshots Stronger than Ever

Since the launch in 2016 of the Cancer Moonshots program under the National Cures Act, the National Cancer Institute (NCI) has invested nearly $1 billion in Moonshots funding, supporting over 240 research projects across more than 70 cancer science initiatives. The program’s mission: to accelerate scientific discovery in cancer, foster greater collaboration, and improve the …

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Cancer Prevention Through Youth, Data, and Collaboration

Cancer is the second leading cause of death globally. Advances in cancer science and medicine are making huge strides in our understanding of what causes cancer. Today’s knowledge and technology, if implemented, can prevent up to 50% of cancers.  On May 6th at 1:10 pm EDT, I will share the podium at the Vatican Pontifical …

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Aveo Pharmaceutical, Advanced-Renal Cell Cancer

New Hope for Advanced Renal Cell Cancer

It’s the dream of every cancer scientist and biotech entrepreneur to bring new hope for cancer sufferers whose therapies are failing. I am so proud of the many talented scientists, clinicians, business leaders and trial participants who contributed to the US Food and Drug Administration’s approval yesterday of AVEO Oncology’s FOTIVDA® (tivozanib) for the treatment of …

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Ron DePinho looks back on 2020, remarkable year in science

2020 Highlights: Top Ten Advances

2020 was a remarkable year in science, not only for COVID research and but also in the cancer research community’s quest to prevent, detect and treat cancers.  Below is my ‘top ten’ list of recent notable advances: (1) COVID-19 Vaccines:Although this is not cancer-specific, the development of vaccines against COVID-19 unquestionably helps cancer patients, whose …

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