JoeDPnew

The Battle for Foundational Research Funding

Twentieth-century health activist Mary Lasker, who devoted her life to securing greater research funding for cancer, is quoted as saying: “If you think research is expensive, try disease.” That battle for adequate cancer research funding is never-ending. Indeed, it’s not just cancer that needs greater funding. Despite advances through the tireless efforts of numerous organizations, …

The Battle for Foundational Research Funding Read More »

Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

Inactivation of the adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal cancers (CRC). APC-deficiency activates WNT signaling which remains an elusive target for cancer therapy, prompting us to apply the synthetic essentiality framework to identify druggable vulnerabilities for APC-deficient cancers. Tryptophan 2,3-dioxygenase …

Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer Read More »

Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

Inactivation of the adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal cancers (CRC). APC-deficiency activates WNT signaling which remains an elusive target for cancer therapy, prompting us to apply the synthetic essentiality framework to identify druggable vulnerabilities for APC-deficient cancers. Tryptophan 2,3-dioxygenase …

Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer Read More »

Graphic depiction of roles of oncogenic KRAS and intratumoral fungi in promoting immune-modulating cytokine IL33 in pancreas cancer.

Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer

Paradigmatic work from PJ Dey’s Lab reveals the co-conspiratory roles of oncogenic KRAS and intratumoral fungi in promoting immune modulating cytokine IL33 in pancreas cancer. This study, published February 3, 2022 in Cancer Cell, expands the therapeutic points of attack for this dreaded disease. Summary: TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate …

Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer Read More »

Ron DePinho MD, on Telomeres in Cancer Aging

Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer

TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the mechanisms by which type 2 immune cells traffic to the tumor microenvironment are unknown. Here, we show that oncogenic KrasG12D increases IL-33 expression in pancreatic ductal adenocarcinoma (PDAC) cells, which …

Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer Read More »

Ron DePinho MD, on Telomeres in Cancer Aging

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer’s Disease Model

Amyloid-induced neurodegeneration plays a central role in Alzheimer’s disease (AD) pathogenesis. Here, we show that telomerase reverse transcriptase (TERT) haploinsufficiency decreases brain-derived neurotrophic factor and increases amyloid-β precursor in the murine brain. Moreover, before disease onset, the TERT locus sustains accumulation of repressive epigenetic marks in murine and human AD neurons, implicating TERT repression in …

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer’s Disease Model Read More »

Ron DePinho MD, on Telomeres in Cancer Aging

Alzheimer’s Disease Research Makes a Paradigm Shift

In this study, we observed that Tert haploinsufficiency affected the expression of genes integral to AD pathogenesis and that neurons from amyloid-based AD models exhibited early epigenetic repression of neuronal TERT expression. We established that physiological increases in TERT levels resulted in a marked reduction of Aβ levels in neurons in the brains of two …

Alzheimer’s Disease Research Makes a Paradigm Shift Read More »

Tvardi Therapeutics: Fiercely Focused on STAT3 Inhibitors

According to life sciences publisher Fierce Biotech, what sets Tvardi Therapeutics apart from other early-stage biotech startups is that “it actually has the data to back up its science.” The company’s first asset is TTI-101 is wrapping up a phase 1 clinical trial in advanced solid tumors and will soon be moving into phase 2. …

Tvardi Therapeutics: Fiercely Focused on STAT3 Inhibitors Read More »

Get Insights From Ron

Sign up for the latest news and updates from Ron DePinho, MD