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Genetic and Biological Hallmarks of Colorectal Cancer

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape …

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Watch On-Demand Sessions: 2021 Fifth International Vatican Council

You can now view all of the speaker sessions from the May 6-8 Fifth International Vatican Conference on the conference website. The 3-day virtual event, offered by the Vatican’s Pontifical Council for Culture and Cura Foundation, featured over 100 global leaders in science, faith, medicine and technology, all exploring and fostering new conversations about how innovation and novel …

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Leadership Series 5: Leading in a Turbulent Time

Leaders have an obligation to continually fine-tune their leadership approach in disruptive times to maximize the success and resilience of their teams. In my last leadership article, I noted that the increasing pace of change in healthcare has increased the need to build more interdependent, highly-adaptive, and high-performing teams. The pandemic has accelerated change and …

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Cancer Moonshots Stronger than Ever

Since the launch in 2016 of the Cancer Moonshots program under the National Cures Act, the National Cancer Institute (NCI) has invested nearly $1 billion in Moonshots funding, supporting over 240 research projects across more than 70 cancer science initiatives. The program’s mission: to accelerate scientific discovery in cancer, foster greater collaboration, and improve the …

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Cancer Prevention Through Youth, Data, and Collaboration

Cancer is the second leading cause of death globally. Advances in cancer science and medicine are making huge strides in our understanding of what causes cancer. Today’s knowledge and technology, if implemented, can prevent up to 50% of cancers.  On May 6th at 1:10 pm EDT, I will share the podium at the Vatican Pontifical …

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Aveo Pharmaceutical, Advanced-Renal Cell Cancer

New Hope for Advanced Renal Cell Cancer

It’s the dream of every cancer scientist and biotech entrepreneur to bring new hope for cancer sufferers whose therapies are failing. I am so proud of the many talented scientists, clinicians, business leaders and trial participants who contributed to the US Food and Drug Administration’s approval yesterday of AVEO Oncology’s FOTIVDA® (tivozanib) for the treatment of …

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Ron DePinho looks back on 2020, remarkable year in science

2020 Highlights: Top Ten Advances

2020 was a remarkable year in science, not only for COVID research and but also in the cancer research community’s quest to prevent, detect and treat cancers.  Below is my ‘top ten’ list of recent notable advances: (1) COVID-19 Vaccines:Although this is not cancer-specific, the development of vaccines against COVID-19 unquestionably helps cancer patients, whose …

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Ron DePinho on Ron DePinho on Telomeres

Telomeres: History, Health, and Hallmarks of Aging

The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify …

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Ron DePinho on Opa Health

How Do We Make Disease Prevention a Reality for Underserved Communities?

Changing mindsets to change behaviors. Up to half of all diseases are preventable with knowledge in hand today and yet we fall short in realizing such social and economic benefit. Moreover, the Covid-19 pandemic has shined a light on an even greater gap in the health and resiliency for underserved communities. For nearly all major …

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November 3rd & 6th, 2021
Animal Models of Cancer Conference

The first genetically engineered mice were created more than 40 years ago. Since then, steady improvements in the field have allowed for the generation of experimentally controllable and genetically accurate models for many human cancers. Recent technological advances in genome editing are pushing this frontier and new animal models are directly impacting precision medicine approaches …

November 3rd & 6th, 2021
Animal Models of Cancer Conference
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