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Ron DePinho MD, on Telomeres in Cancer Aging

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer’s Disease Model

Amyloid-induced neurodegeneration plays a central role in Alzheimer’s disease (AD) pathogenesis. Here, we show that telomerase reverse transcriptase (TERT) haploinsufficiency decreases brain-derived neurotrophic factor and increases amyloid-β precursor in the murine brain. Moreover, before disease onset, the TERT locus sustains accumulation of repressive epigenetic marks in murine and human AD neurons, implicating TERT repression in …

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Ron DePinho MD, on Telomeres in Cancer Aging

Alzheimer’s Disease Research Makes a Paradigm Shift

In this study, we observed that Tert haploinsufficiency affected the expression of genes integral to AD pathogenesis and that neurons from amyloid-based AD models exhibited early epigenetic repression of neuronal TERT expression. We established that physiological increases in TERT levels resulted in a marked reduction of Aβ levels in neurons in the brains of two …

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Tvardi Therapeutics: Fiercely Focused on STAT3 Inhibitors

According to life sciences publisher Fierce Biotech, what sets Tvardi Therapeutics apart from other early-stage biotech startups is that “it actually has the data to back up its science.” The company’s first asset is TTI-101 is wrapping up a phase 1 clinical trial in advanced solid tumors and will soon be moving into phase 2. …

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Protect Your Science and Its Impact

Be strategic in securing intellectual property rights for the benefit of your patients As scientists, we are hardwired to communicate our breakthrough discoveries openly and rapidly in order to advance knowledge for the benefit of humanity. While admirable, scientific publications alone do not cure patients. Alleviation of pain and suffering occurs only when such knowledge …

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Cancer Research and Investment Opportunities

Cancer exacts a steep social and economic toll, especially as an aging world population creates increased cancer rates. The investment community plays a critical role in supporting the conversion of entrepreneurial innovation into products and platforms that reduce the burden of cancer throughout the world. A viable investment strategy rests on an understanding of the …

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Telomere Dysfunction Instigates Inflammation in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, in murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) results in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which …

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Genetic and Biological Hallmarks of Colorectal Cancer

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape …

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Watch On-Demand Sessions: 2021 Fifth International Vatican Council

You can now view all of the speaker sessions from the May 6-8 Fifth International Vatican Conference on the conference website. The 3-day virtual event, offered by the Vatican’s Pontifical Council for Culture and Cura Foundation, featured over 100 global leaders in science, faith, medicine and technology, all exploring and fostering new conversations about how innovation and novel …

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Leadership Series 5: Leading in a Turbulent Time

Leaders have an obligation to continually fine-tune their leadership approach in disruptive times to maximize the success and resilience of their teams. In my last leadership article, I noted that the increasing pace of change in healthcare has increased the need to build more interdependent, highly-adaptive, and high-performing teams. The pandemic has accelerated change and …

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