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Ron DePinho on Opa Health

How Do We Make Disease Prevention a Reality for Underserved Communities?

Changing mindsets to change behaviors. Up to half of all diseases are preventable with knowledge in hand today and yet we fall short in realizing such social and economic benefit. Moreover, the Covid-19 pandemic has shined a light on an even greater gap in the health and resiliency for underserved communities. For nearly all major …

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November 3rd & 6th, 2021
Animal Models of Cancer Conference

The first genetically engineered mice were created more than 40 years ago. Since then, steady improvements in the field have allowed for the generation of experimentally controllable and genetically accurate models for many human cancers. Recent technological advances in genome editing are pushing this frontier and new animal models are directly impacting precision medicine approaches …

November 3rd & 6th, 2021
Animal Models of Cancer Conference
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May 5th, 2021
Fifth International Vatican Conference

The event, hosted by the Vatican’s Secretariat of State, the Pontifical Council for Culture, the Cura Foundation, STOQ Foundation and the Stem for Life Foundation, will convene the world’s leading scientists and physicians, patients, ethicists and leaders of faith, government officials and philanthropists to engage in powerful conversations about the latest scientific breakthroughs and hope …

May 5th, 2021
Fifth International Vatican Conference
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Leadership Series 4: Developing and Leading High-Performing Healthcare Teams

Healthcare leaders are entrusted with setting an inspiring enterprise vision to accelerate medical advances and optimize patient care. This requires that leaders establish an environment and culture of trust, transparency, and shared purpose across the organization. Leaders must also be proficient in developing and building diverse groups of individuals and stakeholders into a cohesive and …

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Telomere dysfunction activates YAP1 to drive tissue inflammation

Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction causes inflammation are not known. Here, we show that telomere dysfunction drives pATM/c-ABL-mediated activation of the YAP1 transcription factor, up-regulating the major pro-inflammatory factor, pro-IL-18. The colonic microbiome stimulates cytosolic receptors activating caspase-1 which …

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Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

Genetic inactivation of PTEN is common in prostate cancer and correlates with poorer prognosis. We previously identified CHD1 as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic evidence for, and mechanistic understanding of, the essential role of CHD1 in PTEN-deficient prostate cancer. In Pten and Pten/Smad4 genetically engineered mouse models, prostate-specific deletion of Chd1 resulted in markedly delayed tumor progression and …

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Sputnik Moment, Ron DePinho

The Covid Moment

This is a pivotal moment, one rife with positive outcomes in the longer term equivalent to those of “The Sputnik Moment” of 1957, when we were caught unawares by the Soviets launching the first rocket into space and then the first missile-bearing rocket. The SARS-CoV-2 pandemic is an unfolding global tragedy, yet a largely preventable …

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Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Oncogenic KRAS (KRAS*) is a key tumor maintenance gene in pancreatic ductal adenocarcinoma (PDAC), motivating pharmacological targeting of KRAS* and its effectors. Here, we explored mechanisms involving the tumor microenvironment (TME) as a potential basis for resistance to targeting KRAS*. Using the inducible KrasG12D p53 null (iKPC) PDAC mouse model, gain-offunction screens of epigenetic regulators …

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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here, we explored the role of oncogenic KRAS in protumorigenic signaling interactions between cancer cells and host cells. We show that KRAS mutation (KRAS*) drives cell-autonomous expression of type I cytokine receptor complexes …

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment Read More »

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSCs). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM, prompting us to conduct a gain-of-function screen of epigenetic regulators that may influence GSC self-renewal and tumor immunity. The circadian …

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