In this study, we observed that Tert haploinsufficiency affected the expression of genes integral to AD pathogenesis and that neurons from amyloid-based AD models exhibited early epigenetic repression of neuronal TERT expression. We established that physiological increases in TERT levels resulted in a marked reduction of Aβ levels in neurons in the brains of two […]
Alzheimer’s Disease Research Makes a Paradigm Shift Read More »
According to life sciences publisher Fierce Biotech, what sets Tvardi Therapeutics apart from other early-stage biotech startups is that “it actually has the data to back up its science.” The company’s first asset is TTI-101 is wrapping up a phase 1 clinical trial in advanced solid tumors and will soon be moving into phase 2.
Tvardi Therapeutics: Fiercely Focused on STAT3 Inhibitors Read More »
Be strategic in securing intellectual property rights for the benefit of your patients As scientists, we are hardwired to communicate our breakthrough discoveries openly and rapidly in order to advance knowledge for the benefit of humanity. While admirable, scientific publications alone do not cure patients. Alleviation of pain and suffering occurs only when such knowledge
Protect Your Science and Its Impact Read More »
Cancer exacts a steep social and economic toll, especially as an aging world population creates increased cancer rates. The investment community plays a critical role in supporting the conversion of entrepreneurial innovation into products and platforms that reduce the burden of cancer throughout the world. A viable investment strategy rests on an understanding of the
Cancer Research and Investment Opportunities Read More »
Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, in murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) results in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which
Telomere Dysfunction Instigates Inflammation in Inflammatory Bowel Disease Read More »
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape
Genetic and Biological Hallmarks of Colorectal Cancer Read More »
You can now view all of the speaker sessions from the May 6-8 Fifth International Vatican Conference on the conference website. The 3-day virtual event, offered by the Vatican’s Pontifical Council for Culture and Cura Foundation, featured over 100 global leaders in science, faith, medicine and technology, all exploring and fostering new conversations about how innovation and novel
Watch On-Demand Sessions: 2021 Fifth International Vatican Council Read More »
Leaders have an obligation to continually fine-tune their leadership approach in disruptive times to maximize the success and resilience of their teams. In my last leadership article, I noted that the increasing pace of change in healthcare has increased the need to build more interdependent, highly-adaptive, and high-performing teams. The pandemic has accelerated change and
Leadership Series 5: Leading in a Turbulent Time Read More »
The U.S. Food & Drug Administration’s announcement on April 29th of a timeline leading to a full ban on mentholated cigarettes and e-cigarettes is one of the most important public health policies of the last few decades. It will be even more impactful if combined with reductions in the nicotine in these products – and
Eliminate Flavored Tobacco and Reduce Nicotine to Non-addictive Levels Read More »
Since the launch in 2016 of the Cancer Moonshots program under the National Cures Act, the National Cancer Institute (NCI) has invested nearly $1 billion in Moonshots funding, supporting over 240 research projects across more than 70 cancer science initiatives. The program’s mission: to accelerate scientific discovery in cancer, foster greater collaboration, and improve the
Cancer Moonshots Stronger than Ever Read More »
Sign up for the latest news and updates from Ron DePinho, MD
