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Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer
Paradigmatic work from PJ Dey’s Lab reveals the co-conspiratory roles of oncogenic KRAS and intratumoral fungi in promoting immune modulating ...
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Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer
TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as interleukin-4 (IL-4), ...
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2021 Cancer Highlights
2021 marked the 20th anniversary of the first human genome draft sequence, which led to such revolutionary landmarks as The ...
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Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer’s Disease Model
Amyloid-induced neurodegeneration plays a central role in Alzheimer’s disease (AD) pathogenesis. Here, we show that telomerase reverse transcriptase (TERT) haploinsufficiency ...
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Alzheimer’s Disease Research Makes a Paradigm Shift
In this study, we observed that Tert haploinsufficiency affected the expression of genes integral to AD pathogenesis and that neurons ...
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Tvardi Therapeutics: Fiercely Focused on STAT3 Inhibitors
According to life sciences publisher Fierce Biotech, what sets Tvardi Therapeutics apart from other early-stage biotech startups is that “it ...
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