Ron

A Single-Dose HPV Vaccine Would Have a Big Impact on Cancer Prevention

As the father of three teenagers, as a son whose father lost his battle with cancer, and as a physician-scientist who specialized in cancer research for more than four decades, I was heartened by the recent and welcome news of continued declines in US cancer mortality rates, driven by continued reductions in tobacco use, increased …

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Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Just in – our paper was selected as the COVER for Cancer Discovery. Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSC). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM, prompting us to conduct a gain-of-function screen …

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Immunometabolism in Pancreatic Cancer

Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment. Authors: Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Huamin Wang, Wen-Ting Liao, Frederick Cavallaro, Parker Denz, Vincent P. Bernard, Er-Yen Yen, Giannicola Genovese, Prateek Gulhati, Jielin Liu, Deepavali Chakravarti, Pingna Deng, Tingxin Zhang, Federica Carbone, Edward Chang, …

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Early Research Shows Potential New Targets in Treating Glioblastoma, Colorectal Cancer, and Pancreatic Ductal Adenocarcinoma

Glioblastoma multiforme, colorectal cancer, and pancreatic ductal adenocarcinoma represent some of the most difficult-to-treat cancers and collectively cause more than 114,000 deaths each year in the United States. A trio of recently published basic research studies in these cancers have found potential therapeutic targets that may help propel the launch of clinical trials in the …

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Leadership Series 3: Achieving Success as a Biotech Leader

There has never been a more opportune time for those in academia and healthcare to accelerate discoveries into advances for treating patients. However, many discoveries often remain trapped in medical journals instead of being fully leveraged to save lives and reduce suffering. To make an impact, academic leaders must encourage and embrace an entrepreneurial spirit …

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